Jumat, 30 Agustus 2013

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Jumat, 23 Agustus 2013

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Sabtu, 17 Agustus 2013

Stop The Thyroid Madness Blog Newsletter

Stop The Thyroid Madness Blog Newsletter


What thyroid patients should know about Oxidative Stress

Posted: 17 Aug 2013 02:21 PM PDT

20130817_151332With a recent Italian study hypothesizing a significant correlation between T4-only levothyroxine use and lung cancer because of “oxidative stress” (possibly due to the serum peak of T4), or the same oxidative stress simply from the hypothyroidism itself, it spurs curiosity as to what oxidative stress is about and what we, as thyroid patients, can learn from this biological phenomena!

Oxidation—what the heck is that?

I have a shampoo holder that hangs from the shower nozzle, and to my dismay, it started to rust underneath the coating. (Note to self: don’t buy a hanging shampoo holder from a garage sale, even if it does look brand new).  And this rust is an example of “oxidation”, i.e. when the iron comes into contact with oxygen (also via moisture), an oxidized corrosion will form called “rust”. Other examples of oxidation are the greenish patina you see on copper, the fading of paint on your house, or the brown coating you'll see on an exposed cut apple…all due to the substance coming in contact with oxygen.

In your body, oxidation is a constant and normal chemical reaction going on every hour, every day and occurring when your cells come into contact with oxygen. It's a required process to supply your body and all its cells with energy. Oxidation helps your body to get rid of old cells in favor of new cells. Your immune system also uses oxidation to attack and kill off pathogens.

Biologically, oxygenation describes the process of any particular molecule (which is made up of connected atoms) coming into contact with oxygen (making it an "oxygenated molecule"), resulting in the loss of an electron—a subatomic particle with a negative electric charge that surrounds any of those atoms. This oxygenated-molecule-minus-an-electron will frantically try to connect with another molecule which does NOT have this electron loss, and this constant attempt of connection produces an unstable "free radical". And free radicals can cause all sorts of havoc.

Fortunately, a healthy and balanced body has a built-in ability to keep these unstable free radicals in check with anti-oxidant defense mechanisms…or at the very least, slow the havoc of a free radical down. Those heroes include several anti-oxidant enzymes, also called free radical scavengers, which can neutralize all those frenzied free radicals. Our body will also use nutrients in what we eat to squelch those free radicals, such as Vitamin C and E. Our bodies have the ability to repair DNA and tissue damage from free radicals, as well as zap damaged cells to death!

When Oxidation become "Oxidative Stress"

On the negative side, sometimes your body can lose the ability to take care of all the free radicals caused by the constant oxidation. (Collectively, all these free radicals are called "reactive oxygen species" (ROS).) The body then becomes overwhelmed by the excess of oxygenated free radicals, causing all sorts of damage. And this is all termed “oxidative stress”. 

Alarmingly, oxidative stress can cause the loss of one of your key and internally-natural antioxidants: glutathione. Glutathione is a powerful antioxidant produced by your own cells, and it neutralizes those free radicals/reactive oxygen species. It also works expertly with antioxidants vitamin C and E. And as your glutathione levels fall, a cascade of toxic deterioration and damage can also begin, from cells to tissues to organs. Scientists theorize, and studies propose, that this is what leads to conditions like:

Oxidative stress may also be negatively affecting your methylation process, such as the MTHFR enzyme.

Dr Andrew Weil explains :

Although we need oxygen to live, high concentrations of it are actually corrosive and toxic. We obtain energy by burning fuel with oxygen – that is, by combining digested food with oxygen from the air we breathe. This is a controlled metabolic process that, unfortunately, also generates dangerous byproducts. These include free radicals – electronically unstable atoms or molecules capable of stripping electrons from any other molecules they meet in an effort to achieve stability. In their wake they create even more unstable molecules that then attack their neighbors in domino-like chain reactions.

Some Causes of oxidative stress

There are quite a few situations mentioned in articles and studies which can cause your body to be overly stressed from the results of oxidation and all the reactive oxygen species. They include, but are not limited to:

  • excess endurance exercising
  • excess weight lifting
  • lack of key antioxidant nutrients like Vitamin C, Vitamin E, Selenium, Magnesium and other minerals
  • excess radiation or sunlight
  • smoking (huge cause of oxidative stress)
  • excessive drinking or drug use
  • over-exposure to toxins in our air, water and foods like pesticides, chemicals, heavy metals and more
  • prescription medications
  • processed foods with all their artificial dyes, additives or flavorings
  • excess physical trauma
  • Graves disease aka hyperthyroidism
  • excess copper levels from the MTHFR defect

Your thyroid condition and Oxidative Stress

In addition to all the above, there are a vast amount of documentation about the strong relationship between hypothyroidism and Oxidative Stress. In just four examples of many:

  1. Oxidative stress and enzymatic antioxidant status in patients with hypothyroidism before and after treatment (http://www.ncbi.nlm.nih.gov/pubmed/17853336):  concludes that "increased ROS levels in hypothyroidism may result in a pro-oxidation environment, which in turn could result in decreased antioxidant PON1 activity, increased MDA (malondialdehyde) and NO (nitric acid) levels". ROS stands for Reactive oxygen species, which are chemically reactive molecules containing oxygen
  2. Serum Lipids and Oxidative Stress in Hypothyroidism http://www.scopemed.org/?mno=34955: found relationship between high Total Cholesterol, Triglycerides, LDL and MDA levels in hypothyroid patients with oxidative stress
  3. Oxidative Stress and Antioxidant Status in Hypo- and Hyperthyroidism http://www.intechopen.com/books/antioxidant-enzyme/oxidative-stress-and-antioxidant-status-in-hypo-and-hyperthyroidism "Despite some contradictory reports, the aforementioned results provide strong evidence that thyroid hormones induce oxidative stress in target tissues."
  4. Oxidative stress status in hypothyroid patients. http://biomedres.info/yahoo_site_admin/assets/docs/286-288-Bhawnadoc.100230858.pdf "Hypothyroidism undeniably can be risk factor for in- creased oxidative stress; can eventually lead to many other complications. Antioxidant therapy and antioxidant diet should be advised along with thyroid hormone replacement therapy to diminish further complications."

What we might conclude as informed thyroid patients

Plenty of research studies and articles underscore that lack of optimal thyroid hormones are strongly associated with your anti-oxidative status in a negative way, meaning the lack of adequate thyroid hormones means oxidative stress. And worldwide thyroid patient reports underscore the reality of a potential, hypothyroid-induced "oxidative stress profile" with their chronic inflammation and finding themselves more frequent illnesses, besides lowered levels of important nutrients (due to hypothyroid-induced low stomach acid) which can end up contributing to oxidative stress. In other words, all too many patients have reported continued hypothyroidism while being on T4-only, or they reporting seeing symptoms of hypothyroidism creep up the longer they stay on T4-only. Continued hypothyroidism can occur if you are undertreated even on Natural Desiccated Thyroid or T3-only thanks to being held hostage to the TSH lab test (or issues with untreated low cortisol).

Conversely, informed thyroid patients could surmise that proper treatment of their hypothyroid state, in addition to their acquire low iron, low nutrient, low cortisol state, could strongly improve their anti-oxidative status in a positive way. And reported patient experience in the use of Natural Desiccated Thyroid may be underscoring this, as well. Namely, patients who switch from T4 to NDT report far better health outcomes i.e. less sicknesses, better well-being, lowered inflammation.

In the meantime, the same four Italian researchers who did the study on T4-only, lung cancer and oxidative stress may eventually provide us with more tips to counter this issue.

Ten suggested strategies for informed thyroid patients to consider to counter oxidative stress

  1. Be on a thyroid treatment which gives the best results, and thus, may play a role in lowering your oxidative stress, which reported patient experience reveals to be natural desiccated thyroid (or adding T3 to you T4 treatment, or even being on T3-only).
  2. Get a wide variety of antioxidants in foods.
  3. Optimize and balance your blood sugar levels
  4. Identify and address your food intolerances
  5. Optimize your gut health
  6. Treat your low cortisol
  7. Dr. Kharrazian recommends the following nutrients: N-acetyl-cysteine (NAC), Alpha Lipoic Acid (ALA), L-Glutamine, Selenium, Cordyceps, Gotu kola and Milk thistle. (Learn about each before using)
  8. Consider meditation and/or Yoga or any other stress-busting activities
  9. Find ways to laugh…and laugh….and laugh!
  10. Get plenty of sleep.

Discuss all the above with your doctor so he or she can be included in your team approach to your health and well-being. Let’s STOP THE THYROID AND OXIDATIVE STRESS MADNESS! :)

***********************

** Want to chat with other patients concerning this oxidative stress issue? See a list of good thyroid patients groups.

** Need a good doctor to be in partnership with you? Here are strategies to help you.

** Like to learn in book form about better thyroid treatment? Order the Bible of better thyroid treatment as learned by patients (and the publishing company, with each order of the STTM book, is giving away a FREE 4-page handout on Herbs which help thyroid patients, for a limited time!)

** Check out this neat video by Tyler DeWitt explaining the difference between an atom and a molecule.

** For a very technical description of free radicals, check out the "Radical" Wikipedia article.

** See a list of diseases and conditions caused by oxidative stress on the Oxidative Stress Resource website. . http://www.oxidativestressresource.org/

 

Jumat, 16 Agustus 2013

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Selasa, 13 Agustus 2013

Stop The Thyroid Madness Blog Newsletter

Stop The Thyroid Madness Blog Newsletter


More BAD news if you are on T4-only like Synthroid: it can cause Lung Cancer, says a study!

Posted: 12 Aug 2013 07:49 PM PDT

LungsAfter worldwide patient experience has revealed that T4-only treatment results in a slew of continuing hypothyroid symptoms, now we have a study which reveals that T4-only treatment could be raising your risk of LUNG CANCER!!

This complete study came out just last Thursday, August 8, 2013, in the Reproductive Biology and Endocrinology journal and it’s certainly not good news on top of what thyroid patients already know has been a failure in so many ways.

The Italian authors said the correlation between lung cancer and T4-only treatment was “significant“!

In other words, as hypothyroid patients raise their T4-only levothyroxine medication to chase continuing symptoms of hypothyroidism, it can lead to medication-induced hyperthyroid state, which in turns leads to an overproduction of oxidative stress. The latter is a known cause of cancer and other chronic diseases. But with T4-use, it’s specifically problematic for lung cancer.

Oxidative stress can be defined as a that which results in “significant decrease in the effectiveness of your inherant antioxidant defenses, such as glutathione” (Wikipedia). And there are two main consequences:  your body doesn’t detoxify itself well, nor does it repair any damage well because of free radicals.

The study states:

The prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 was correlated with the sales of LT4 in 2009. The cancer prevalence was analyzed in women aged 30–84. This age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers. The correlation between sales of LT4 and cancers was determined with the technique of Density Ellipses. The age and smoking contribution for lung cancer was determined with the Sequential test.

It also adds:

Lung cancer was the only tumor found directly correlated with LT4 supplementation.

It’s particularly interesting to note that simply being hypothyroid results in increased oxidative stress, but the use of T4-only medications creates the same problem via a different route, explains the study. “LT4 can alter the oxidative balance in lungs and behave as a negative factor because of oxidative stress….” 

The authors conclude that “hypothyroidism might also be involved in the development of lung cancer”, but the study does send an alarming message about the correlation between T4 use and lung cancer, as well.

The website Green Med Info, which promotes natural and integrative modalities, goes further into the discussion about the problematic nature of treating hypothyroidism with T4-only, stating

One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore ‘back up’ causing excessive T4 activity, i.e. hyperthyroidism. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a ‘TSH suppressor.’ This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic ‘self-fulfilling prophecy’ if you will.

And they conclude: “There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight.” And of course, patients who have switched to natural desiccated thyroid (NDT) have reported FAR better results repeatedly! Brands are not limited to Armour. Other brands which patients like include Erfa, Acella (NP Thyroid), Naturethroid, Westhroid-P and more.

Message to those still using T4-only

Millions of hypothyroid patients have reported millions of prices in their own degree and kind thanks to their use of T4-only medications….sooner or later. Now we have a study that implies your risk of getting lung cancer is increased! What’s next?? It’s not a pretty picture. Time to take a strong and open-minded look at what patients have learned.